Set in present day, the story follows the adventures of "good old boy" cousins, Bo (Seann William Scott) and Luke (Johnny Knoxville) Duke, who with the help of their eye-catching cousin Daisy (Jessica Simpson) and moonshine running Uncle Jesse (Willie Nelson), try and save the family farm from being destroyed by Hazzard County's corrupt commissioner Boss Hogg (Burt Reynolds).
Their efforts constantly find the "Duke Boys" eluding authorities in "The General Lee," their famed 1969 orange Dodge Charger that keeps them one step ahead of the dimwitted antics of the small southern town's Sheriff Roscoe P. Coltrane (M.C. Gainey).
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