Young lovers Sailor and Lula take off for New Orleans following Sailor's release from prison, with Lula's hysterical mother, a weary detective and a sinister hitman after them. During their journey, Lula and Sailor relate the events of their lives to date, while encountering a typical gallery of Lynch grotesques. After being stranded in a small town, Sailor agrees to join the loathsome Bobby Peru in a criminal venture.
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