Poor 10-year-ol Lucas Nickle (voiced by Zach Tyler Eisen) can’t get a break. Recently moved to a new city with his family, he hasn’t made a single friend. He gets nothing but grief from his teenage sister Tiffany (voiced by Allison Mack) and not a whole lot of attention lately from his parents (voiced by Cheri Oteri and Larry Miller), who are busy planning their big anniversary week-end trip to Puerto Vallarta. Meanwhile, his loving but kinda kooky grandmother Mommo (voiced by Lilly Tomlin) spends all her time trying to protect the family from those outer-space aliens she’s been reading about in the grocery store magazines.
To make matters worse, Lucas has become the number one target of local bully Steve (voiced by Myles Jeffrey), who never misses an opportunity to push him around. In turn, Lucas delights in destroying ant hills in his front yard – venting his frustration on the defenceless mounds of dirt and their tiny inhabitants by kicking them, stomping them and squirting them with the garden hose.
But, unbeknownst to Lucas, there is a whole world alive and busy under his feet and what he sees as “just a bunch of little ants” are actually members of a complex society, with names and relationships, responsibilities and emotions. They’re getting mighty tired of having their homes trampled by Lucas the Destroyer. And they’re ready to fight back.