In the middle of a raging thunderstorm a travelling circus accidentally leaves behind some very precious cargo – a baby zebra (voiced by Frankie Muniz). The gangly little foal is rescued by horse farmer Nolan Walsh (Bruce Greenwood) who takes him home to his young daughter Channing (Hayden Panettiere). Once a champion thoroughbred trainer, Walsh has given up horse training for a quiet life with Channing on their modest Kentucky farm.
The little zebra, or “Stripes,” as Channing calls him is soon introduced to the farm’s misfit troupe of barnyard residents, led by a grumpy Shetland Pony named Tucker (voiced by Dustin Hoffman).
Stripes and Channing both hold the same ambition, to compete in and win the nearby Kentucky Derby. As he thrusts himself into a world of elite athletes, intense competition and enormous stakes, Stripes must prove he’s fast enough and tough enough to run with the big horses if he wants to land in the winner’s circle at the legendary Kentucky Open.